- Is able to perform its desired function with respect to a medical therapy.
- Generates the most appropriate beneficial cellular or tissue response.
- Elicits no undesirable local or systemic effects in the recipient.
Appropriate and adequate immune response with a proper activation of the immune cells takes place, including a directed biological response, a good host-implant integration, a desired healing process as well as in the case of wear-in-duced immune reaction the possible encapsulation of wear particles and their removal.
Metal ions that are eluted into the peri-implant space or generated by wear and corrosion at the modular junction can either accumulate locally within cells and tissues which surround the implant. However these metal ions can also spread systemically via their transportation through the blood stream and hence can accumulate in distant organs (e.g. liver, heart, spleen ...) that can lead to metal intoxication, which can cause long-term systemic complications to the organism.
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